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Feeling hot or cold Unusual hunger and weight gain Dry mouth Fatigue and dizziness Heart problems such as abnormal rhythms Blood pressure changes (increase or decrease) Anecdotal side effects Anxiety and loss of sleep (Taking in AM and early afternoon helped (having doses around 250-350mg))

56, 57 Data quality was assessed with phenix.xtriage tool 58 within the PHENIX suite of programs, 52, 59 while the phasing of experimental data for wild-type CstB was done by molecular replacement using PHASER 60 as implemented in PHENIX

65 ) (Addgene, 52961) for CRISPRCas9 KO or into pLV hU6-sgRNA hUbC-dCas9-KRAB-T2a-Puro 66 (Addgene, 71236) for CRISPRi knockdown, as previously described 41

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